Are COVID Vaccines Showing Signs of Containing the Pandemic?
Early signs suggest vaccines are helping drive down infection rates in some countries, including Israel and the UK.
More than 130 million COVID vaccine doses have been administered worldwide already, according to the University of Oxford’s “” vaccination tracker.
Israel, the United Kingdom, the United States, the United Arab Emirates and China are leading this huge global effort. COVID vaccines were initially tested and approved on their ability to reduce the severity of the disease.
However, the long-term goal of vaccination is to decrease infection rates and eliminate the virus. Excitingly, early signs suggest vaccines are already helping drive down infection rates in some countries, including Israel and the UK.
In saying that, it’s early days, and some preliminary data suggest countries might have to update their vaccine strategies to deal with emerging variants of the virus.
Israel is Leading the Way
The US (43 million doses), China (40 million) and the UK (13 million) have administered the .
However, these numbers don’t take into account population size, so looking at the number of doses injected per 100 people is more meaningful.
Here, the league table is currently topped by per 100 people. of the population are fully vaccinated with both doses. And all this in just five weeks. to vaccinate everyone over the age of 16 and reach at least 80% of its nine million people by May this year.
Reaching at least 70% of the population via vaccination (and/or natural infection) is needed for herd immunity for COVID, according to initial modelling by University of Chicago researchers in May last year.
However, given more infectious variants of the virus have emerged, we may need to to reach herd immunity.
Infection Rates Are Falling So far, Israel is solely using the Pfizer/BioNTech vaccine. Interim reports from the country suggest the vaccine rollout is linked to a fall in infections in people over 60 years old.
It can be tricky to separate the effects of public health measures such as lockdowns versus the effects of vaccination.
But because the fall is most pronounced in older people who were first in line to receive the vaccine, this is also partly due to the vaccine, and .
A team of Israeli researchers larger falls in infections and hospitalisations after the vaccinations than occurred during previous lockdowns.
Only 0.07% of the 750,000 over-60s vaccinated tested positive for COVID, according to Israeli Ministry of Health data released last week. And only 38 people, or 0.005%, fell ill and required hospitalisation. The chance of testing positive for COVID two weeks after receiving the first dose was 33% lower than in those not vaccinated.
The UK is Also Showing Positive Signs
The UK has administered . Around 13.2 million people (or one in five adults) , and 0.5 million have the second dose.
It’s currently using both the Pfizer/BioNTech and Oxford University/AstraZeneca vaccines in its rollout.
The infection rate appears to be decreasing substantially. The current daily infection growth rate by between 2-5%, and the R number is to be between 0.7 and 1 (an R number of less than 1 means daily new cases will decrease over time).
However, it’s difficult to determine whether these numbers are due to the lockdown or vaccinations. It’s too early to tell whether vaccines are slowing transmission, but the signs are encouraging.
According to data from the Oxford/AstraZeneca vaccine group, and yet to be peer reviewed, its vaccine is showing signs of reducing transmission. The shot was associated with a 67% reduction in transmission among vaccinated volunteers in clinical trials in the UK.
What Threatens the Successful Rollout of Vaccines?
There are three main problems that might hinder the success of this global vaccination drive.
1. Vaccine development, manufacturing, distribution and delivery
The world’s population over the age of five is currently estimated at seven billion people. If we need to vaccinate at least 70% of them to achieve herd immunity, we need to reach around five billion people.
This is an enormous undertaking, so vaccine production and availability are crucial. Many countries face the massive challenge of producing or securing enough vaccines to immunise all their citizens.
Generally, wealthier countries that could afford to make advanced purchase agreements with vaccine producers — or who could manufacture a vaccine domestically — have been the first to start COVID vaccinations.
Unfortunately, partial vaccination of the world’s population won’t achieve herd immunity. suggests if high-income countries exclusively acquire the first two billion doses without regard for vaccine equity, the number of COVID deaths could double worldwide.
2. Administering, monitoring, and reporting adverse effects
Vaccinating a large number of citizens quickly can’t be done with existing health institutions alone.
It’s urgent we enable alternative sites such as halls and sporting venues to be used as mass vaccination sites. We also need to allow a range of health professions such as medical students, public health officials and pharmacists to administer doses to help speed up the process.
And once vaccines have been administered, it’s crucial we monitor efficacy and report on any adverse effects, which will require additional resources.
3. Vaccine effectiveness and virus mutation
The effectiveness of vaccines can be hindered by of the virus. COVID variants originating in Brazil, South Africa, and the UK have triggered huge concern worldwide.
If vaccines become less effective, new vaccines will need to be developed either including a booster dose incorporating the region of the mutated virus, or to include the mutated strains.
This, however, isn’t uncommon — flu vaccines are required to be updated regularly in order to increase protective capacity against new mutated strains.
(Maximilian de Courten is professor in Global Public Health and Director of the Mitchell Institute, Victoria University. Maja Husaric is senior lecturer, MD, Victoria University. Vasso Apostolopoulos is Professor of Immunology and Pro Vice-Chancellor, Research Partnerships, Victoria University)
(This article was originally published on The Conversation. Read the original article here.)
(Subscribe to FIT on Telegram)
Subscribe To Our Daily Newsletter Now.