Will Coronavirus Mutations Affect the Current Vaccine Development?
One fear is that critical parts of coronavirus genome will mutate, making any vaccine obsolete before it’s out.
“Coronavirus” has already established itself as the scary new word of 2020. Add the word “mutant”, and you’ve got an even stronger candidate for the scary new phrase of 2021.
One fear is that critical parts of the coronavirus genome will mutate, making any vaccine obsolete before it’s widely rolled out next year.
But how much of an issue is this really? As we’ll see, SARS-CoV-2, the coronavirus that causes COVID-19, mutates, as do all viruses. But unlike other RNA viruses, it’s actually quite stable.
What’s a Mutation Anyway?
In genetic terms, a mutation is just a scary word for a mistake. As cells make new copies of a virus, mistakes happen. These mistakes sometimes result in a stronger virus, sometimes a weaker virus.
In fact, SARS-CoV-2 seems to have a slower rate of mutation than . That’s because it belongs to a family of viruses with that can identify and remove most mistakes in its RNA when the virus replicates.
What About Mutations and Spike Proteins?
This is why vaccines are typically designed against these critical regions — to safeguard against mutations that would make them ineffective.
This is the protein many COVID-19 vaccines use to generate a protective immune response. In fact, the Australia has signed agreements for, should they pass clinical trials, all the virus’ spike protein or carry the instructions your body needs to make it.
What’s All This to do With Mink?
Syringes At Ten Paces
Considering what we know about how the virus mutates and the rate of these mutations, the first generation of COVID-19 vaccines look likely to provide some protection currently circulating SARS-CoV-2 strains.
Since January, scientists around the world have generated and made publicly available more than COVID-19 genomes. Scientists can then compare these with the early COVID-19 genomes sequenced in Wuhan. These early sequences are the templates for the vaccines we are waiting impatiently for.
This surveillance will provide an early warning system for potentially critical mutations. And if researchers find mutations, they need to work out what these mutations actually do, using so-called “functional tests”.
Such tests can tell us whether a new mutation influences our immune response to the spike protein, compared to those induced by the original Wuhan strain. We can also investigate if antibodies following vaccination can continue to bind to the spike protein of emerging strains and prevent the virus from infecting human cells.
So Should We Be Worried?
Researchers have only been able to study this coronavirus for a very short time. So only time will tell if it mutates at a frequency and at limited positions in the essential regions, as we have come to expect. That’s why surveillance is so important.
The current crop of vaccines have been developed using decades of accumulated scientific knowledge and are based on what we know about mutations in this and other coronaviruses. So we shouldn’t be too worried when we read scary headlines about a “”.
This past year has demonstrated the capacity to rapidly produce vaccines, which hopefully can be modified to reflect new mutations and merging strains should they occur.
(This is an opinion piece and the views expressed above are the author’s own. The Quint neither endorses nor is responsible for the same. This article was originally published on The Conversation. Read the original article here.)
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