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Lead Exposure Can Be a Risk Factor for Alzheimer’s Disease: ICMR

Lead Exposure Can Be a Risk Factor for Alzheimer’s Disease: ICMR

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Research conducted at the Indian Council of Medical Research - National Institute of Nutrition (ICMR-NIN) has established a possible link between lead exposure and Alzheimer’s disease. This adds to the bulk of evidence for the adverse health impact of this common pollutant, which is found in commonly used materials like paints, cosmetics, batteries, glass, and low-grade toys.

In a press release dated 13 January, the national council said, “Environmental exposure to this toxic heavy metal is associated with many pathophysiological dysfunctions of the central nervous system.”

Led by senior scientist Dr Suresh Challa, the research discovered the molecular mechanism by which lead-induced toxicity leads to the development of Alzheimer’s disease through in vitro studies.

The scientists also concluded that maternal exposure to lead during pregnancy can cause developmental reprogramming, leading to a higher risk and early onset of Alzheimer’s later on in the child’s life.

On the other hand, the studies found therapeutic potential in natural compounds such as catechins, especially epigallocatechin gallate (EGCG) present in foods like green tea, guava leaves, apples, cherries, pears, blackberries which possess antioxidant, anti-inflammatory and metal chelant properties. It was concluded that EGCG is “protective against lead toxicity and can effectively decrease neuronal cell death.”

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